Allen HK, Donato J, Wang HH, Cloud-Hansen KA, Davies J, Handelsman J: Call of the wild: antibiotic resistance genes in natural environments. Nat Rev Microbiol 2010, 8: 251–259. 10.1038/nrmicro2312
Article
CAS
PubMed
Google Scholar
Alonso A, Sanchez P, Martinez JL: Environmental selection of antibiotic resistance genes. Environ Microbiol 2001, 3: 1–9. 10.1046/j.1462-2920.2001.00161.x
Article
CAS
PubMed
Google Scholar
Baudoux P, Bles N, Lemaire S, Mingeot-Leclercq MP, Tulkens PM, Van Bambeke F: Combined effect of pH and concentration on the activities of gentamicin and oxacillin against Staphylococcus aureus in pharmacodynamic models of extracellular and intracellular infections. J Antimicrob Chemother 2007, 59: 246–253.
Article
CAS
PubMed
Google Scholar
Beck E, Ludwig G, Auerswald EA, Reiss B, Schaller H: Nucleotide sequence and exact localization of the neomycin phosphotransferase gene from transposon Tn5. Gene 1982, 19: 327–336. 10.1016/0378-1119(82)90023-3
Article
CAS
PubMed
Google Scholar
Bibb MJ, Janssen GR, Ward JM: Cloning and analysis of the promoter region of the erythromycin resistance gene (ermE) of Streptomyces erythraeus. Gene 1985, 38: 215–226. 10.1016/0378-1119(85)90220-3
Article
CAS
PubMed
Google Scholar
Butler MS, Cooper MA: Screening strategies to identify new antibiotics. Curr Drug Targets 2012, 13: 373–387. 10.2174/138945012799424624
Article
CAS
PubMed
Google Scholar
Criswell D, Tobiason VL, Lodmell JS, Samuels DS: Mutations conferring aminoglycoside and spectinomycin resistance in Borrelia burgdorferi. Antimicrob Agents Chemother 2006, 50: 445–452. 10.1128/AAC.50.2.445-452.2006
Article
CAS
PubMed Central
PubMed
Google Scholar
Davies J, Davies D: Origins and evolution of antibiotic resistance. Microbiol Mol Biol Rev 2010, 74: 417–433. 10.1128/MMBR.00016-10
Article
CAS
PubMed Central
PubMed
Google Scholar
Elowitz MB, Levine AJ, Siggia ED, Swain PS: Stochastic gene expression in a single cell. Science 2002, 297: 1183–1186. 10.1126/science.1070919
Article
CAS
PubMed
Google Scholar
Forsberg KJ, Reyes A, Wang B, Selleck EM, Sommer MO, Dantas G: The shared antibiotic resistome of soil bacteria and human pathogens. Science 2012, 337: 1107–1111. 10.1126/science.1220761
Article
CAS
PubMed Central
PubMed
Google Scholar
Gyssens IC: Antibiotic policy. Int J Antimicrob Agents 2011,38(Suppl):11–20.
Article
CAS
PubMed
Google Scholar
Hassett DJ, Imlay JA: Bactericidal antibiotics and oxidative stress: a radical proposal. ACS Chem Biol 2007, 2: 708–710. 10.1021/cb700232k
Article
CAS
PubMed
Google Scholar
Hermann T: Aminoglycoside antibiotics: old drugs and new therapeutic approaches. Cell Mol Life Sci 2007, 64: 1841–1852. 10.1007/s00018-007-7034-x
Article
CAS
PubMed
Google Scholar
Kaufman M, Soule C, Thomas R: A new necessary condition on interaction graphs for multistationarity. J Theor Biol 2007, 248: 675–685. 10.1016/j.jtbi.2007.06.016
Article
CAS
PubMed
Google Scholar
Kieser T, Bibb MJ, Buttner MJ, Chater KF, Hopwood DA: Practical Streptomyces Genetics. John Innes centre, Norwich Research Park, Norwich; 2000.
Google Scholar
Kohanski MA, Dwyer DJ, Hayete B, Lawrence CA, Collins JJ: A common mechanism of cellular death induced by bactericidal antibiotics. Cell 2007, 130: 797–810. 10.1016/j.cell.2007.06.049
Article
CAS
PubMed
Google Scholar
Lederberg J, Lederberg EM: Replica plating and indirect selection of bacterial mutants. J Bacteriol 1952, 63: 399–406.
CAS
PubMed Central
PubMed
Google Scholar
Levy SB: The challenge of antibiotic resistance. Sci Am 1998, 278: 46–53.
Article
CAS
PubMed
Google Scholar
Levy SB: The Antibiotic Paradox: How the Misuse of Antibiotics Destroys Their Curative Power. Da Capo Press, Perseus Publishing, Cambridge, MA, USA; 2002.
Google Scholar
Long KS, Poehlsgaard J, Hansen LH, Hobbie SN, Bottger EC, Vester B: Single 23S rRNA mutations at the ribosomal peptidyl transferase centre confer resistance to valnemulin and other antibiotics in Mycobacterium smegmatis by perturbation of the drug binding pocket. Mol Microbiol 2009, 71: 1218–1227. 10.1111/j.1365-2958.2009.06596.x
Article
CAS
PubMed
Google Scholar
Losick R, Desplan C: Stochasticity and cell fate. Science 2008, 320: 65–68. 10.1126/science.1147888
Article
CAS
PubMed Central
PubMed
Google Scholar
Mahajan GB, Balachandran L: Antibacterial agents from actinomycetes - a review. Front Biosci (Elite Ed) 2012, 4: 240–253.
Article
Google Scholar
Martinez JL: Antibiotics and antibiotic resistance genes in natural environments. Science 2008, 321: 365–367. 10.1126/science.1159483
Article
CAS
PubMed
Google Scholar
Mattie H: Antibiotic efficacy in vivo predicted by in vitro activity. Int J Antimicrob Agents 2000, 14: 91–98. 10.1016/S0924-8579(99)00145-4
Article
CAS
PubMed
Google Scholar
Mehra S, Charaniya S, Takano E, Hu WS: A bistable gene switch for antibiotic biosynthesis: the butyrolactone regulon in Streptomyces coelicolor. PLoS One 2008, 3: e2724. 10.1371/journal.pone.0002724
Article
PubMed Central
PubMed
Google Scholar
Mitrophanov AY, Groisman EA: Positive feedback in cellular control systems. Bioessays 2008, 30: 542–555. 10.1002/bies.20769
Article
CAS
PubMed Central
PubMed
Google Scholar
Nikaido H: Multidrug resistance in bacteria. Annu Rev Biochem 2009, 78: 119–146. 10.1146/annurev.biochem.78.082907.145923
Article
CAS
PubMed Central
PubMed
Google Scholar
Seghezzi N, Amar P, Koebmann B, Jensen PR, Virolle MJ: The construction of a library of synthetic promoters revealed some specific features of strong Streptomyces promoters. Appl Microbiol Biotechnol 2011, 90: 615–623. 10.1007/s00253-010-3018-0
Article
CAS
PubMed
Google Scholar
Shin JH, Singh AK, Cheon DJ, Roe JH: Activation of the SoxR regulon in Streptomyces coelicolor by the extracellular form of the pigmented antibiotic actinorhodin. J Bacteriol 2011, 193: 75–81. 10.1128/JB.00965-10
Article
CAS
PubMed Central
PubMed
Google Scholar
Ward JM, Janssen GR, Kieser T, Bibb MJ, Buttner MJ: Construction and characterisation of a series of multi-copy promoter-probe plasmid vectors for Streptomyces using the aminoglycoside phosphotransferase gene from Tn5 as indicator. Mol Gen Genet 1986, 203: 468–478. 10.1007/BF00422072
Article
CAS
PubMed
Google Scholar