AMB Express

Codon harmonization reduces amino acid misincorporation in bacterially expressed P. falciparum proteins and improves their immunogenicity

Authors of this study developed a strategy to “recode” target gene sequences for heterologous expression by substituting native codons with synonymous alternates with identical or similar usage frequencies in the expression host. This approach has been termed “codon harmonization”, which here was applied to the malarial antigen, CelTOS. CelTOS is a highly conserved P. falciparum protein involved in cellular traversal through mosquito and vertebrate host cells.

Editor's quote

The high quality journal, AMB Express, was founded as a fully open access sister journal to Applied Microbiology and Technology about 6 years ago. Since then, the journal has become well-known to authors and reviewers whilst steadily growing. This year, we already have more than 400,000 downloads. Meanwhile, AMB Express has had several achievements: following indexing by ISI, it has since received two consecutive Thomson Reuters Science Citation Index Impact Factors. These Impact Factors were unexpectedly high, and we are very confident that they will continue to grow. What is, however, most important is that not only the number of manuscripts is increasing, but also their volume and the quality of their contents. The editors of AMB Express, the managing editor and I, will ensure that the journal’s performance and the quality of the published papers will continue to improve and that more excellent and highly cited papers will be published in AMB Express. Papers devoted to ‘Industrial Microbiology’ and with a particular interest in ‘White and Red Biotechnology’ are highly welcome; this also includes short papers in which important achievements are communicated.

Alexander Steinbüchel, Editor-in-Chief
(October 2018)
University of Münster