Figure 4

Circular treemaps visualizing differentially expressed functional protein categories. Proteins detected by mass spectrometry were clustered according to their pathway annotation in COG covering two levels of specificity (Tatusov et al. [1997]). The size of a sector is proportional to the number of proteins found in one specific pathway in relation to the total protein number. The color code represents the log₂ mean fold change (log₂ FC) of protein quantity in one pathway. The color blue codes for an underrepresentation, red for an overrepresentation of the proteins in a pathway compared to the reference population (RP, μ = 0.2 h⁻¹). Pathways with a fold change in the range log₂ FC < −0.58 and log₂ FC > 0.58 are labeled with the respective pathway name. Pathways that were significantly changed using GAGE (Luo et al. [2009]) and Globaltest (Goeman et al. [2006]) gene set analysis are additionally marked (*). a. Comparison of the subpopulations C1/C2 and C2/Cx at growth rates 0.1 h⁻¹ and 0.7 h⁻¹, respectively. b. Comparison of the subpopulations C1 and C2 at μ = 0.1 h⁻¹ with RP. c. Comparison of the subpopulations C2 and Cx at μ = 0.7 h⁻¹ with RP.