Table 2 Comparison of strategies and yields of doxorubicin-producing strains
Strain | Strategies | Reported production(mg/L) | References |
|---|---|---|---|
S. peucetius | Doxorubicin-resistance selection, deletion gene dnrU, | 1406 in shake flask | This study |
△U1/drrC | overexpression resistance gene drrC and medium optimization | 1461 in 10 L fermenter | |
SIPI-11 | Classical strain mutation and medium optimization | 570 in shake flask, 1100 in 5 L fermenter | (Wang et al. 2018) |
ATCC27952 | Overexpression of coaA and coaE genes | 3 in shake flask | (Lee et al. 2014) |
ATCC27952 | Overexpression of the global regulatory gene afsR | 80 in shake flask | (Parajuli et al. 2005) |
ATCC 29,050 | Inactivation doxorubicin-modifying enzymes dnrX | 41.3 in shake flask | (Lomovskaya et al. 1998) |