Table 3 Drug-likeness characteristics of natural flavonoid glycosides including Fisetin, Kaempferol, Morin, Myricetin, and Quercetin
Drug-likeness properties | Fisetin | Kaempferol | Morin | Myricetin | Quercetin |
|---|---|---|---|---|---|
Molecular weight (g/mol) | 286.24 | 286.24 | 302.24 | 318.24 | 302.24 |
Number of H-bond acceptor | 6 | 6 | 7 | 8 | 7 |
Number of H-bond donor | 4 | 4 | 5 | 6 | 5 |
Number of rotatable bonds | 1 | 1 | 1 | 1 | 1 |
TPSA (Ã…2) | 111.13 | 111.13 | 131.36 | 151.59 | 131.36 |
Log Po/w (iLOGP) | 1.50 | 1.70 | 1.47 | 1.08 | 1.63 |
Lipinski’s rule of five violation | Yes; 0 violation | Yes; 0 violation | Yes; 0 violation | Yes; 1 violation | Yes; 0 violation |
Bioavailability score | 0.55 | 0.55 | 0.55 | 0.55 | 0.55 |