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AMB Express

Table 3 Synergistic antimicrobial activity between AKBA and AMK against MRSA and MSSA clinical isolates

From: Drug repurposing: insights into the antimicrobial effects of AKBA against MRSA

Strains

Resistant Pattern

Antimicrobial

MICalone

MICin combination

Fold Change

FICI

Outcome

SA2301

MRSA

AKBA

8

2

0.25

0.5

Synergy

AMK

4

1

0.25

SA2302

MRSA

AKBA

8

2

0.25

0.5

Synergy

AMK

8

2

0.25

SA2303

MRSA

AKBA

8

1

0.125

0.375

Synergy

AMK

2

0.5

0.25

SA2304

MRSA

AKBA

8

2

0.25

0.5

Synergy

AMK

4

1

0.25

SA2305

MRSA

AKBA

8

1

0.125

0.375

Synergy

AMK

0.5

0.125

0.25

SA2306

MRSA

AKBA

8

2

0.25

0.375

Synergy

AMK

8

1

0.125

SA2307

MRSA

AKBA

4

1

0.25

0.5

Synergy

AMK

8

2

0.25

SA2308

MRSA

AKBA

8

1

0.125

0.25

Synergy

AMK

2

0.25

0.125

SA2309

MRSA

AKBA

8

2

0.25

0.5

Synergy

AMK

4

1

0.25

SA2310

MRSA

AKBA

4

1

0.25

0.5

Synergy

AMK

8

2

0.25

SA23101

MSSA

AKBA

4

0.5

0.125

0.375

Synergy

AMK

1

0.25

0.25

SA23102

MSSA

AKBA

4

1

0.25

0.375

Synergy

AMK

2

0.25

0.125

SA23103

MSSA

AKBA

8

2

0.25

0.5

Synergy

AMK

2

0.5

0.25

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