Drug repurposing: insights into the antimicrobial effects of AKBA against MRSA

AMB Express

Table 2 Synergistic antimicrobial activity between AKBA and GEN against MRSA and MSSA clinical isolates

Strains	Resistant Pattern	Antimicrobial	MIC_alone	Fold Change	MIC_{in combination}	FICI	Outcome
SA2301	MRSA	AKBA	8	2	0.25	0.5	Synergy
SA2301	MRSA	GEN	16	4	0.25	0.5	Synergy
SA2302	MRSA	AKBA	8	1	0.125	0.25	Synergy
SA2302	MRSA	GEN	32	4	0.125	0.25	Synergy
SA2303	MRSA	AKBA	8	2	0.25	0.375	Synergy
SA2303	MRSA	GEN	16	2	0.125	0.375	Synergy
SA2304	MRSA	AKBA	8	2	0.25	0.5	Synergy
SA2304	MRSA	GEN	16	4	0.25	0.5	Synergy
SA2305	MRSA	AKBA	8	0.5	0.063	0.188	Synergy
SA2305	MRSA	GEN	> 32	4	0.125	0.188	Synergy
SA2306	MRSA	AKBA	8	2	0.25	0.313	Synergy
SA2306	MRSA	GEN	32	2	0.063	0.313	Synergy
SA2307	MRSA	AKBA	4	0.5	0.125	0.188	Synergy
SA2307	MRSA	GEN	32	2	0.063	0.188	Synergy
SA2308	MRSA	AKBA	8	2	0.25	0.281	Synergy
SA2308	MRSA	GEN	32	1	0.031	0.281	Synergy
SA2309	MRSA	AKBA	8	2	0.25	0.375	Synergy
SA2309	MRSA	GEN	32	4	0.125	0.375	Synergy
SA2310	MRSA	AKBA	4	1	0.25	0.375	Synergy
SA2310	MRSA	GEN	16	2	0.125	0.375	Synergy
SA23101	MSSA	AKBA	4	1	0.25	0.375	Synergy
SA23101	MSSA	GEN	2	0.25	0.125	0.375	Synergy
SA23102	MSSA	AKBA	4	1	0.25	0.5	Synergy
SA23102	MSSA	GEN	2	0.5	0.25	0.5	Synergy
SA23103	MSSA	AKBA	8	1	0.125	0.375	Synergy
SA23103	MSSA	GEN	4	1	0.25	0.375	Synergy