Table 1 Summary of calculated pharmacokinetic parameters using a log-linear trapezoidal method for VGRmIL2-IC, wtIL-2, and mIL-2 following intravenous administration in mice
From: A novel nanobody-based immunocytokine of a mutant interleukin-2 as a potential cancer therapeutic
Proteins | AUC(0–t) (ng. h/ml) | AUC(0–∞) (ng. h/ml) | t1/2 (h) | CL/F (ml/h/kg) | Ke (h−1) | MRT (h) |
|---|---|---|---|---|---|---|
VGRmIL2-IC | 4361.954 | 4459.913 | 2.83 | 0.67 | 0.245 | 2.78203 |
wtIL-2 | 947.7558 | 977.9066 | 1.74 | 2.78 | 0.398 | 1.219605 |
mIL-2 | 1304.598 | 1331.933 | 1.58 | 1.57 | 0.439 | 1.541295 |