Fig. 6

In silico modeled show pi-diagram of natural compound ligand (Vit D3, Curcumin, Vit C, and Quercetin) by Swiss target prediction tool. Indicate target prediction. Ligand highly hits different targets. A Vitamin D3 target 26.7% nuclear receptor. The muted BDNF gene, interactions of vitamin D3 with GPCRs, and associated signaling pathways may be of interest. B Curcumin target 20% Oxidoreductase and enzyme. curcumin interacts with oxidoreductases and kinases in the context of compensatory mechanisms, or by modifying the BDNF-related effects caused by mutations C Vitamin C highly target 33.3% phosphatase. Vitamin C interacts with phosphatases and kinases in the context of compensatory mechanisms or moderating effects of BDNF-related mutations D Quercetin target 33.3% oxidoreductase. BDNF activity is impaired, the capacity of quercetin to interact with these enzymes may affect neuroprotection