Total transcriptome analysis of Candida auris planktonic cells exposed to tyrosol

AMB Express

Table 1 Tyrosol-induced oxidative stress response in Candida auris

Oxidative stress related parameter	Untreated cultures	Tyrosol-treated cultures
2’,7’–dichlorofluorescein [nmol DCF (OD₆₄₀)⁻¹]	7.1 ± 1.9	16.8 ± 3.9^*
Superoxide dismutase [munit (mg protein)⁻¹]	54.3 ± 6.1	78.1 ± 14.8 ^*
Catalase [kat (kg protein)⁻¹]	0.6 ± 0.2	1.2 ± 0.35 ^*
Glutathione reductase [mkat (kg protein)⁻¹]	2.2 ± 0.5	2.8 ± 0.3
Glutathione peroxidase [mkat (kg protein)⁻¹]	0.2 ± 0.02	0.29 ± 0.06 ^*
Reduced glutathione [nmol (OD₆₄₀)^{− 1}]	49.8 ± 5.4	65.1 ± 4.0 ^*
Oxidized glutathione [nmol (OD₆₄₀)^{− 1}]	0.2 ± 0.04	0.26 ± 0.04

Mean ± standard deviation values calculated from three independent biological replicates are presented
^{*, ***} Significant differences at p < 0.05 and 0.001, respectively, as calculated by the paired Student’s t-test compared to untreated control and tyrosol-treated cultures