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Fig. 2 | AMB Express

Fig. 2

From: Heparanase is the possible link between monkeypox and Covid-19: robust candidature in the mystic and present perspective

Fig. 2

Heparanase (HPSE) and macrophage activation: HPSE activates resting macrophage to be converted to activated macrophage with activation of cytokine receptors. HPSE via HPSE receptors increases expression of Fgr1 and NF-κB which induces expression and release of pro-inflammatory cytokines like IL-6 and IL-2. HPSE and pro-inflammatory cytokines also stimulate the activated macrophage to release more of pro-inflammatory cytokines

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