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AMB Express

Table 4 Antibacterial activity of A. hydaspica: isolated fractions/compounds from AHE by flash chromatography (ISCO)

From: Bioassay-guided isolation and characterization of lead antimicrobial compounds from Acacia hydaspica plant extract

Antibacterial activity

Microorganism

Samples

Gram + ive

Gram − ive

S. aureus

E. faecalis

B. Subtilis

E. coli

P. aeruginosa

K. pneumoniae

A. baumannii

% GI

% GI

% GI

% GI

% GI

% GI

% GI

AHE/F3

91 ± 1.17*,+++

44 ± 1.23

90 ± 1.71*,+++

99 ± 0.99*,+++

46 ± 0.87

31 ± 0.98

25 ± 0.56

AHE/F5

21 ± 0.67

18 ± 0.31

46 ± 1.01

62 ± 1.10+++

15 ± 0.16

8.0 ± 0.62

11 ± 0.13

AHE/F7

24 ± 0.52

16 ± 0.27

70 ± 1.30+++

24 ± 0.18

1.0 ± 0.02

6.6 ± 0.25

− 3 ± 0.05

Tetracycline

95 ± 1.21

–

99 ± 1.79

96 ± 1.43

94 ± 1.13

95 ± 1.11

96 ± 1.17

Penicillin G

–

94 ± 1.66

–

–

–

–

–

Antifungal activity

Microorganism

 

Yeast

Fungi

Sample

C. neoformans

C. albicans

F. solani

A. niger

% GI

% GI

% GI

% GI

AHE/F3

20.62 ± 0.34

30.3 ± 0.41

87.2 ± 0.94*

86.3 ± 1.0*

Amphotericin B

94.90 ± 1.05

82.70 ± 0.96

90.1 ± 1.01

92.4 ± 1.11

  1. Values are expressed as mean ± SEM (n = 3). Significant activity = more than 70% growth inhibition; Good activity = 60–70% growth inhibition; Moderate activity = 50–60% growth inhibition; non-significant below 50% growth inhibition. Symbol (–) represents not done. GI (growth inhibition at 100 µg/ml)
  2. *Indicate highest growth inhibitory potential (GI %) of fraction, and fraction with * activity was subjected for further testing to get MIC50 values and structure elucidation
  3. +++Indicated significant (p < 0.0001) inhibitory potential of selected fraction compared to other fractions. Data analyzed by One-way ANOVA followed by Tukey’s comparison analysis
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