Table 10 Summary of optimization studies for biomass (DCW) and setomimycin production by Streptomyces sp. RA-WS2
Optimization stage | Medium | Biomass (DCW g/L) | Fold increase in Biomass (DCW) production | Setomimycin (mg/L) | Fold increase in setomimycin production |
|---|---|---|---|---|---|
Initial fermentation conditions | PM-2 | 2.4 | 1 | 40 | 1 |
Medium optimization | PM-7 | 3.3 | 1.3 | 55 | 1.3 |
Optimization of physical parameters | PM-7 | 3.7 | 1.54 | 63 | 1.5 |
Optimization of carbon and nitrogen source | Modified PM-7 | 26 | 11 | 408 | 10.2 |
Optmization by Taguchi L9 othogonal array design | Modified PM-7 | 40 | 16.6 | 675 | 16.8 |