Fig. 7

The synergistic activity in mice peritonitis model. A Flowchart for the formation of peritonitis model infected MDR E. coli Y9633 and the treatment regimen was followed. Agar plate counting of E. coli in mouse B kidney, C liver, D lung, and E spleen homogenate. ***p < 0.001. The graphs were the result of averaged three separate trials. F H&E staining pathological slice of mouse liver (the plotting scale is 50 μm). Inflammatory cell infiltration and bacterial burden can be effectively reduced in the combination group. Vehicle represented DMSO injection. The group that received 20 mg/kg of tavaborole was referred to as Tava. TOB and Tava + TOB served as 4 mg/kg TOB-treated group and 20 mg/kg Tava + 4 mg/kg TOB, respectively. G For 7 days, the survival rates of peritonitis mice treated with various dosing regimens had been observed