Table 4 Expression levels of osteogenic marker genes at 24 h after rhBMP-2 treatment
Gene | E-rhBMP-2 | C-rhBMP-2 | |||
|---|---|---|---|---|---|
Abbreviation | Full name | Log2FC | P-value | Log2FC | P-value |
Oasis | Old astrocyte specifically induced substance | 1.29 | 9.64 × 10–9 | 3.20 | 1.70 × 10–66 |
TIEG1 | TGF-β-inducible early gene | 0.84 | 2.08 × 10–2 | 1.37 | 3.71 × 10–5 |
Id3 | Inhibitor of DNA Binding 3 | 1.60 | 1.53 × 10–27 | 1.69 | 1.00 × 10–30 |
Runx2 | BMP-2-induced runt-related transcription factor 2 | 0.70 | 7.99 × 10–2 | 1.83 | 1.81 × 10–8 |
Col1 | Type 1 collagen | 2.60 | 2.88 × 10–21 | 4.38 | 1.34 × 10–84 |
OSX | Osterix | 6.12 | 8.45 × 10–15 | 7.77 | 2.33 × 10–40 |
OPG | Osteoprotegerin | 3.21 | 5.01 × 10–1 | 7.11 | 2.28 × 10–10 |
OPN | Osteopontin | − 1.39 | 2.08 × 10–32 | -2.93 | 7.33 × 10–108 |
OCN | Osteocalcin | 4.96 | 2.06 × 10–3 | 7.54 | 2.14 × 10–16 |