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AMB Express

Table 1 Binding kinetic parameters of E-rhBMP-2 and C-rhBMP-2

From: Modulation of osteogenic differentiation by Escherichia coli-derived recombinant bone morphogenetic protein-2

Ligand

Analyte

ka (L/Ms)

kd (L/s)

KD (M)

Rmax (RU)

E-rhBMP-2

BMPR1A

1.03 × 104

1.57 × 10–4

1.52 × 10–8

223.2

BMPR1B

1.96 × 103

3.80 × 10–4

1.94 × 10–7

43.6

BMPR2

6.07 × 103

8.47 × 10–4

1.40 × 10–7

107.2

C-rhBMP-2

BMPR1A

1.18 × 104

1.29 × 10–4

1.09 × 10–8

347.5

BMPR1B

3.47 × 103

2.58 × 10–4

7.43 × 10–8

109.9

BMPR2

4.85 × 103

6.86 × 10–4

1.41 × 10–7

222.2

  1. ka, association rate; kd, dissociation rate; KD, equilibrium dissociation rate constant; Rmax, analyte binding capacity of the surface
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