Table 3 Coefficients and ANOVA results for the reduced combinatorial model
From: Development of a perfusion process for serum-free adenovirus vector herpes zoster vaccine production
Termsa | Titer | CSVYb | Foldc | |||
|---|---|---|---|---|---|---|
Coefficient | P value | Coefficient | P value | Coefficient | P value | |
Constant | 3.13E + 11 | < 0.001 | − 6.51E + 04 | < 0.001 | − 2.69E + 04 | 0.02 |
MOI | 2.44E + 09 | 0.21 | −7.05E + 02 | 0.09 | 9.98E + 02 | < 0.001 |
TOI | 1.08E + 09 | 0.29 | 3.45E + 03 | < 0.001 | 1.06E + 03 | < 0.001 |
pH | 4.56E + 10 | < 0.001 | 9.75E + 03 | < 0.001 | 4.09E + 03 | 0.02 |
MOI*MOI | 1.53E + 07 | 0.72 | − 6.52E−01 | 0.89 | 6.70E + 00 | 0.03 |
TOI*TOI | 8.32E + 07 | 0.22 | 1.76E + 00 | 0.81 | 8.78E + 00 | – |
MOI*TOI | 3.04E + 07 | 0.42 | 1.10E + 01 | 0.03 | − 1.75E + 02 | < 0.001 |
MOI*pH | 4.46E + 08 | 0.81 | 8.08E + 01 | 0.70 | − 1.66E + 02 | 0.09 |
TOI*pH | 2.73E + 06 | 1.00 | − 5.27E + 02 | 0.04 | − 2.69E + 04 | 0.18 |
Regression | – | 0.01 | – | 0.00 | – | 0.00 |
Lack of fit | – | 0.38 | – | 0.42 | – | 0.08 |