Fig. 3
Histopathological examination of rat skin from: a group I (No wound) showing the normal histological structure of the epidermis, dermis, subcutaneous tissue and adipose tissue as well as musculature; b group II (Wound, Infection, Untreated) showing focal necrosis and hyalinization were detected in the epidermis, dermis and extended to subcutaneous tissue in association with inflammatory cells infiltration and collagen proliferation; c group III (Wound, Infection, Vehicle) showing focal atrophy in the epidermis while the underlying dermis showed fibrosis. Focal few inflammatory cells infiltration was detected in the subcutaneous tissue; d group IV (Wound, no Infection, Untreated) showing focal fibrosis was detected in the dermis directly underneath the epidermis associated with oedema and few inflammatory cells infiltration in subcutaneous tissue; e group V (Wound, Infection, Treated with Formula 1) showing focal acanthosis in the epidermis accompanied by hyalinization in the underlying dermis as well as musculature. The subcutaneous tissue showed fibrosis with inflammatory cells infiltration and edema; f group VI (Wound, Infection, Treated with Formula 2) showing focal acanthosis in the epidermis while the underlying dermis had fibrosis. The subcutaneous tissue showed inflammatory cells infiltration and focal hemorrhage; g group VII (Wound, Infection, Treated with Formula 3) showing no histopathological alteration in the skin epidermis and dermis while the subcutaneous adipose tissue showed congestion in the blood vessels; h group VIII (Wound, Infection, Treated with Formula 4) showing no histopathological alteration in the skin epidermis, dermis, subcutaneous tissue and musculature