In vivo evaluation of a recombinant N-acylhomoserine lactonase formulated in a hydrogel using a murine model infected with MDR Pseudomonas aeruginosa clinical isolate, CCASUP2

AMB Express

Table 4 Log viable count of P. aeruginosa in different organs of animals in different animal groups (P value < 0.001)

Group	Description	Mean bacterial count ± SD
Group	Description	Blood Log no. of CFU/ml	Lung Log no. of CFU/g	Liver Log no. of CFU/g
Group N	Normal (control)	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0
Group B	Burned uninfected (control)	1.84 ± 0.39	1.69 (0.5)	1.602 ± 0.28
Group C	Burned, infected, untreated (control)	4.68 ± NA^a	4.7 ± NA^a	5.05 ± NA^a
Group 1	Burned, infected treated with Ahl-1 lactonase hydrogel (test)	0.536 ± 0.09	1 ± 0.29	2.3 ± 0.41
Group 2	Burned, infected, treated with vehicle (control for vehicle)	3.78 ± 1.2	5.114 ± 0.3	4.6 ± 0.56