Identification of the molecular mechanisms underlying brisket disease in Holstein heifers via microbiota and metabolome analyses

AMB Express

Table 3 Taxonomic analysis at the phylum, family, and genus levels

Category	HH (n = 5)	BD (n = 5)	P
Phylum
Firmicutes	64.75 ± 2.87	49.94 ± 7.31	< 0.001
Bacteroidetes	30.38 ± 5.49	43.30 ± 8.70	0.010
F/B	2.22 ± 0.62	1.23 ± 0.47	0.022
Family
Ruminococcaceae	34.34 ± 4.94	17.84 ± 3.49	< 0.001
Rikenellaceae	15.69 ± 0.05	6.76 ± 4.29	0.006
Genus
Ruminococcaceae_UCG-005	14.21 ± 5.32	7.55 ± 2.55	0.017
Ruminococcaceae_UCG-013	2.85 ± 0.97	0.91 ± 0.66	0.002
Ruminococcaceae_UCG-009	0.78 ± 0.130	0.37 ± 0.091	0.019
Ruminococcus-2	0.65 ± 0.088	0.17 ± 0.053	< 0.001
Ruminococcaceae_UCG-014	0.52 ± 0.150	0.07 ± 0.028	0.008
Dorea	0.33 ± 0.041	0.09 ± 0.022	< 0.001
Marvinbryantia	0.28 ± 0.061	0.07 ± 0.018	0.006
Eubacterium_hallii_group	0.26 ± 0.088	0.08 ± 0.018	0.043
Blautia	0.24 ± 0.078	0.06 ± 0.016	0.030
Eubacterium_brachy_group	0.22 ± 0.021	0.09 ± 0.032	0.004
Lachnospiraceae_UCG-001	0.13 ± 0.045	0.0212 ± 0.011	0.019
Oscillospira	0.11 ± 0.017	0.0470 ± 0.018	0.017
Anaerosporobacter	0.10 ± 0.037	5.60E−03 ± 3.100E−03	0.013
Lachnospiraceae_FE2018_group	0.04 ± 0.0114	9.70E−03 ± 4.000E−03	0.019
Candidatus_Hepatincola	0.02 ± 0.0110	3.48E−04 ± 3.000E−04	0.007
Coprobacillus	0.02 ± 4.60E−03	4.20E−03 ± 3.800E−03	0.017