An endophytic Schizophyllum commune Fr. exhibits in-vitro and in-vivo antidiabetic activity in streptozotocin induced diabetic rats

AMB Express

Table 2 Effect of S. commune extract on creatinine, BUN, FeNa, and potassium level in STZ induced diabetic rats

Groups	Creatinine (mg/dl)	BUN (mg/dl)	FeNa (%)	Potassium (mmol)
NC	0.756 ± 0.107	39.52 ± 9.123	3.214 ± 0.545	4.856 ± 1.374
DC	1.77 ± 0.165^a	91.71 ± 12.781^a	12.716 ± 2.847^a	11.374 ± 2.304^a
PC	0.852 ± 0.172^b	50.656 ± 6.577^b	5.513 ± 1.016^b	4.264 ± 1.299^b
SC50	1.188 ± 0.133^a,b	69.666 ± 4.302^a,b	7.588 ± 0.776^a,b	8.054 ± 1.006^a,b
SC100	0.872 ± 0.092^b,c	51.444 ± 2.374^b,c	5.226 ± 1.246^b	4.528 ± 0.482^b,c

Data are expressed as mean ± S.D. (n = 5). NC: normal healthy control; DC: diabetic control; PC: positive control (STZ induced diabetic rats treated with reference drug acarbose (60 mg/kg body weight)); SC50 and SC100: STZ induced diabetic rats treated with S. commune extract (50 and 100 mg/kg body weight respectively)
^aP < 0.05 Different control groups when compared with normal group
^bP < 0.05 Diabetic control group when compared with other treated groups
^cP < 0.05 S. commune extract treated groups when compared with each other