Table 1 Phospho/Unphospho Ratio change in F4ac∆faeG vs F4ac infected cells
From: Deletion of FaeG alleviated Enterotoxigenic Escherichia coli F4ac-induced apoptosis in the intestine
Phosphorylation site | Gene symbol | F4ac∆faeG Phospho/Unphospho ratio (mean ± SD) | F4ac Phospho/Unphospho ratio (mean ± SD) | Fold change (F4ac∆faeG/F4ac) | Apoptosis process or type |
|---|---|---|---|---|---|
Abl1 (Phospho-Tyr204) | ABL1 | 0.217 ± 0.017 | 0.114 ± 0.016 | 1.90 | Intrinsic (or mitochondrial) |
ASK1 (Phospho-Ser83) | MAP3K5 | 1.347 ± 0.248 | 0.852 ± 0.233 | 1.58 | Intrinsic (or mitochondrial) |
XIAP (Phospho-Ser87) | XIAP | 0.563 ± 0.013 | 0.919 ± 0.050 | 0.61 | Intrinsic |
FKHR (Phospho-Ser256) | FOXO1 | 1.039 ± 0.075 | 2.172 ± 1.433 | 0.48 | Intrinsic or extrinsic |
Cyclin D1 (Phospho-Thr286) | CCND1 | 0.213 ± 0.101 | 0.411 ± 0.263 | 0.52 | Intrinsic |
p44/42 MAPK (Phospho-Tyr204) | MAPK3 | 1.102 ± 0.003 | 1.775 ± 0.722 | 0.62 | Not specific |
BID (Phospho-Ser78) | BID | 0.418 ± 0.233 | 0.673 ± 0.093 | 0.62 | Intrinsic or extrinsic |
Caspase 3 (Phospho-Ser150) | CASP3 | 0.888 ± 0.019 | 1.352 ± 0.037 | 0.66 | Intrinsic or extrinsic |
Caspase 9 (Phospho-Tyr153) | CASP9 | 0.194 ± 0.079 | 0.333 ± 0.088 | 0.58 | Intrinsic or extrinsic |
CDK2 (Phospho-Thr160) | CDK2 | 1.087 ± 0.017 | 2.234 ± 0.078 | 0.49 | DNA damage (related to FOXO1) |
Cortactin (Phospho-Tyr421) | CTTN | 1.217 ± 0.009 | 5.418 ± 0.196 | 0.22 | Extrinsic |
GSK3 alpha (Phospho-Ser21) | GSK3A | 1.147 ± 0.060 | 1.955 ± 0.797 | 0.59 | Intrinsic or extrinsic |
NFkB-p100/p52 (Phospho-Ser869) | RELA | 1.761 ± 0.696 | 0.955 ± 0.033 | 1.84 | Not specific |
Raf1 (Phospho-Ser259) | RAF1 | 4.060 ± 0.444 | 2.561 ± 2.560 | 1.59 | Intrinsic (related to ASK1) |
STAT3 (Phospho-Tyr705) | STAT3 | 0.858 ± 0.017 | 1.307 ± 0.566 | 0.66 | Intrinsic or extrinsic |
NFkB-p65 (Phospho-Thr435) | RELA | 2.020 ± 1.050 | 3.192 ± 0.443 | 0.63 | Not specific |
SP1 (Phospho-Thr739) | SP1 | 1.082 ± 0.052 | 3.159 ± 2.783 | 0.34 | Not specific |
LYN (Phospho-Tyr507) | LYN | 0.134 ± 0.064 | 0.242 ± 0.035 | 0.55 | Not specific |
HSP27 (Phospho-Ser82) | HSPB1 | 1.344 ± 0.084 | 2.209 ± 0.424 | 0.61 | Intrinsic |
Ezrin (Phospho-Thr566) | EZR | 0.514 ± 0.269 | 0.293 ± 0.004 | 1.75 | Not specific (related to XIAP) |
GRB10 (Phospho-Tyr67) | GRB10 | 1.093 ± 0.006 | 0.712 ± 0.239 | 1.53 | Not specific (related to Bim) |
Synuclein alpha (Phospho-Tyr125) | SNCA | 0.993 ± 0.030 | 2.209 ± 1.905 | 0.45 | Intrinsic |
VEGFR2 (Phospho-Tyr1175) | KDR | 1.034 ± 0.097 | 1.924 ± 1.630 | 0.54 | Intrinsic |
PKC zeta (Phospho-Thr410) | PRKCZ | 0.947 ± 0.016 | 2.130 ± 1.783 | 0.44 | Extrinsic (related to Fas) |
Estrogen Receptor-alpha (Phospho-Ser104) | ESR1 | 2.412 ± 0.150 | 0.728 ± 0.285 | 3.31 | Extrinsic |
Estrogen Receptor-alpha (Phospho-Ser167) | ESR1 | 1.159 ± 0.015 | 2.406 ± 1.570 | 0.48 | Extrinsic |
CaMK2A (Phospho-Thr286) | CAMK2A | 0.318 ± 0.015 | 0.206 ± 0.013 | 1.54 | Ca2+-dependent apoptosis |
eEF2K (Phospho-Ser366) | EEF2K | 1.011 ± 0.005 | 0.654 ± 0.183 | 1.54 | Intrinsic or extrinsic |
Ras-GRF1 (Phospho-Ser916) | RASGRF1 | 0.609 ± 0.071 | 0.396 ± 0.007 | 1.54 | Not specific |