Table 1 Productivity and growth characteristics of selected trastuzumab-expressing CHO-K1 clones in batch culture (chemically defined, protein-free medium and shaking culture)
Clones | VCDmax (106 cells/mL) | IVCC (108 cells*h/mL) | μmax (h−1) | Duration (days) | [IgG]max (μg/mL) | qIgG (pcd) |
|---|---|---|---|---|---|---|
5B12 | 7.7 | 811.59 | 0.0237 | 8 | 58.88 ± 3.55 | 3.8 |
6C8 | 6.925 | 729.97 | 0.0247 | 8 | 69.01 ± 2.24 | 3.86 |
1B6 | 7.1 | 723.01 | 0.0196 | 8 | 80.08 ± 3.68 | 4.05 |