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Table 1 Productivity and growth characteristics of selected trastuzumab-expressing CHO-K1 clones in batch culture (chemically defined, protein-free medium and shaking culture)

From: Screening and selection strategy for the establishment of biosimilar to trastuzumab-expressing CHO-K1 cell lines

Clones VCDmax (106 cells/mL) IVCC (108 cells*h/mL) μmax (h−1) Duration (days) [IgG]max (μg/mL) qIgG (pcd)
5B12 7.7 811.59 0.0237 8 58.88 ± 3.55 3.8
6C8 6.925 729.97 0.0247 8 69.01 ± 2.24 3.86
1B6 7.1 723.01 0.0196 8 80.08 ± 3.68 4.05
  1. VCDmax maximum viable cell density, IVCC time integral of viable cell concentration, μmax maximum growth rate, qIgG specific productivity