Microbial keratinase and the bio-economy: a three-decade meta-analysis of research exploit

Nnolim, Nonso E.; Nwodo, Uchechukwu U.

doi:10.1186/s13568-020-01155-8

AMB Express

Table 5 A few selected keratinase research innovation patents in the past three decades (1990–2019)

From: Microbial keratinase and the bio-economy: a three-decade meta-analysis of research exploit

Title	Patent number	Region	Weblink	Inventor	Legal status^a
Immobilization of keratinase for proteolysis and keratinolysis	US20030108991A1	United States	https://patents.google.com/patent/US20030108991A1/en	Shih et al.	Abandoned
Keratinase mutant that a kind of substrate specificity improves and preparation method thereof	CN104726436B	China	https://patents.google.com/patent/CN104726436B/en	Zhang et al.	Active
Keratinase and production method thereof	JP5699261B2	Japan	https://patents.google.com/patent/JP5699261B2/en	Watanabe et al.	Active
Novel metal ion-tolerant keratinase and application thereof	CN108060170B	China	https://patents.google.com/patent/CN108060170B/en	Shi et al.	Active
Keratinase mutant with improved thermal stability and preparation method thereof	CN104017791B	China	https://patents.google.com/patent/CN104017791B/en	Chen et al.	Active
Development of an asporogenic Bacillus licheniformis and production of keratinase therefrom	US20060127982A1	United States	https://patents.google.com/patent/US20060127982A1/en	Jason Shih	Abandoned
Hari cosmetic composition comprising keratinase for protection of hair and repair of hair damage	KR101207490B1	South Korea	https://patents.google.com/patent/KR101207490B1/en	Kang and Kim	Terminated
Alkali keratinase, dna encoding the same and method for using the same	JP2011155932A	Japan	https://patents.google.com/patent/JP2011155932A/en	Inoue et al.	Pending
Keratinase and gene sequence and application method thereof	CN106350530A	China	https://patents.google.com/patent/CN106350530A/en	Gong et al.	Active
Signal peptide for optimizing efficient secretory expression of keratinase (Ker) and application thereof	CN107200772B	China	https://patents.google.com/patent/CN107200772B/en	Zeng et al.	Active
A kind of fermentation process efficiently producing keratinase using recombination bacillus coli	CN105316306B	China	https://patents.google.com/patent/CN105316306B/en	Zhang et al.	Active
A kind of isolation and purification method of keratinase and application	CN105821023B	China	https://patents.google.com/patent/CN105821023B/en	Bian et al.	Active
Keratinase mutant that a kind of catalytic rate improves and preparation method thereof	CN105002152B	China	https://patents.google.com/patent/CN105002152B/en	Zhang et al.	Active
Cleaning agent containing keratinase	DE102016214383A1	Germany	https://patents.google.com/patent/DE102016214383A1/en	Walter Haberlein	Withdrawn
Keratinase produced by Bacillus licheniformis	US5877000A	United States	https://patents.google.com/patent/US5877000A/en	Burtt and Ichida	Expired
Detergent containing keratinase	DE102016214382A1	Germany	https://patents.google.com/patent/DE102016214382A1/en	Haberlein and Stehr	Withdrawn
Enzymatic formulation of lotion containing microbial keratinase as sole depilatory agent and drug absorption promoter	BR102014021563A2	Brazil	https://patents.google.com/patent/BR102014021563A2/en	Macedo et al.	Discontinued
Heat stable keratinase and use thereof	DK3027746T3	Denmark	https://patents.google.com/patent/DK3027746T3/en	Ho et al.	Active
A method of preparing feather albumen powder using alkali protease and keratinase	CN104798981B	China	https://patents.google.com/patent/CN104798981B/en	Hao et al.	Terminated
It is a kind of produce keratinase Pseudomonas aeruginosa and its application	CN105861373B	China	https://patents.google.com/patent/CN105861373B/en	Huang et al.	Active
Method of preparing feather protein powder from keratinase	CN104770574A	China	https://patents.google.com/patent/CN104770574A/en	Lujiang et al.	Terminated
Pearl albefaction method mediated by keratinase and combined with redox	CN100579412C	China	https://patents.google.com/patent/CN100579412C/en	Zhang et al.	Active
Produce Bacillus cereus and its application of keratinase	CN107868762A	China	https://patents.google.com/patent/CN107868762A/en	Bian et al.	Active
Method for producing amino acid by hydrolyzing feather with keratinase	CN110760550A	China	https://patents.google.com/patent/CN110760550A/en	Zhang et al.	Active
Strain of bacterium Bacillus licheniformis as producer of keratinase	RU2177994C2	Russia	https://patents.google.com/patent/RU2177994C2/en	Tsurikova et al.	Invalid
A kind of compounding of keratinase and application in the industrial production	CN107916308B	China	https://patents.google.com/patent/CN107916308B/en	Shi et al.	Active
Novel keratinase derived from thermophilic bacteria and use thereof	KR101785613B1	South Korea	https://patents.google.com/patent/KR101785613B1/en	Lee et al.	Active
Heat stable keratinase and uses thereof	TWI564390B	Taiwan	https://patents.google.com/patent/TWI564390B/en	Mengqiao et al.	N/A
Method for producing bacterial strain and efficiently degrading feathers by using keratinase	CN107828847B	China	https://patents.google.com/patent/CN107828847B/en	Zhang et al.	Active
DNA encoding Bacillus licheniformis PWD-1 keratinase	US5712147A	United States	https://patents.google.com/patent/US5712147A/en	Shih et al.	Expired
The keratinase mutant and application that a kind of catalytic performance improves	CN109593746A	China	https://patents.google.com/patent/CN109593746A/en	Shi et al.	Active
The method and its application of gold nanoparticle preparation are carried out using keratinase	CN109456958A	China	https://patents.google.com/patent/CN109456958A/en	Yu et al.	Active
A kind of keratinase mutant being transformed through thermal stability	CN108949729A	China	https://patents.google.com/patent/CN108949729A/en	Gong et al.	Active
Stenotrophomonas maltophilia for generating keratinase and application of Stenotrophomonas maltophilia	CN102329751B	China	https://patents.google.com/patent/CN102329751B/en	Chen et al.	Active
Removal of biological deposits	US20200315943A1	United States	https://patents.google.com/patent/US20200315943A1/en	Speight and Navone	Pending
Cosmetics for hair removal	JP3923424B2	Japan	https://patents.google.com/patent/JP3923424B2/en	Maeda and Yamamoto	Active
Composition and method for destruction of infectious prion proteins	US6613505B2	United States	https://patents.google.com/patent/US6613505B2/en	Jason Shih	Active
Degradation of beta-amyloid proteins with keratinase	US20170042980A1	United States	https://patents.google.com/patent/US20170042980A1/en	Kirk Johnson	Abandoned
A method of improving keratinase vigor	CN109797145A	China	https://patents.google.com/patent/CN109797145A/en	Wang et al.	Active

^aN/A not available

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