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Table 1 Comparison of octanol/water partition coefficient values determined by the shake-flask method and calculated by the theoretical method

From: Enhancement of the antioxidant and skin permeation properties of eugenol by the esterification of eugenol to new derivatives

Compound

log P1 average value

log P2

Eugenol

2.20 ± 0.001c

2.49

EChA

2.43 ± 0.001ab

3.11

EDChA

2.65 ± 0.001ab

3.73

ETChA

2.75 ± 0.002a

4.35

DChAA

0.95 ± 0.002e

0.80

TChAA

1.51 ± 0.002d

1.42

  1. 1 determined by the shake-flask method; mean ± S.D. (n = 3)
  2. 2 log P calculated in the MestReNova program, different letters–values are significantly different, mass substance in the acceptor fluid (P < 0.001)
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