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AMB Express

Table 2 Effects of nisin, licorice polyphenols (glabridin, licoricidin, licochalcone A), and chlorhexidine at a sub-inhibitory concentration (1/4 MIC) on biofilm formation by E. faecalis ATCC 19433

From: Biocompatible combinations of nisin and licorice polyphenols exert synergistic bactericidal effects against Enterococcus faecalis and inhibit NF-κB activation in monocytes

Compound (µg/mL)

Relative growth (%)

Biofilm formation (%)

None

102.3 ± 2.5

101.5 ± 4.9

Nisin (3.125 µg/mL)

109.1 ± 9.9

76.5 ± 6.6*

Glabridin (6.25 µg/mL)

101.4 ± 2.9

103.8 ± 6.8

Licoricidin (1.56 µg/mL)

104.4 ± 2.2

68.4 ± 4.9*

Licochalcone A (3.125 µg/mL)

97.1 ± 0.9

91.4 ± 8.7

Chlorhexidine (1.56 µg/mL)

106.8 ± 3.7

62.5 ± 1.5*

  1. *Significant reduction (p < 0.01) compared to control cultures without compounds
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