Fig. 4

Detection of the clinical symptoms, weight changes, lung indexes, and number of T cells in the lungs of the mice from different groups. Each group had 6 mice. a1, a2 The clinical symptoms of each mouse were observed and scored at 0, 6, 12, 24, 48 and 72 h after challenge. b1, b2 The weight of each mouse was recorded at 0, 6, 12, 24, 48, and 72 h after challenge, and the weight changes of the mice were calculated (weight changes = the initial weight- the real-time weight); * represents the RTAC1 group or the IB5-C1 group or the IB1-C1 group compared with the PBSC1 group and was statistically significant; # represents the RTAC5 group or the IB1- C5 group or the IB5-C5 group compared with the PBSC5 group and was statistically significant. c The body weight and the lung weight of the mice were recorded at 72 h after challenge, and the lung indexes of the mice were calculated. d The mice in the RTAC5 and PBSC5 groups were challenged with APP5b. The number of T cells in the lungs was detected by flow cytometry at 72 h after challenge. * or #, P < 0.05; ** or ##, P < 0.01