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AMB Express
Fig. 4 | AMB Express

Fig. 4

From: The role of autophagy in the cytotoxicity induced by trastuzumab emtansine (T-DM1) in HER2-positive breast cancer cells

Fig. 4

Inhibition of autophagy reduced T-DM1-induced apoptosis in SK-BR-3 cells and BT-474 cells. SK-BR-3 cells and BT-474 cells are exposed to corresponding concentrations of T-DM1 with or without 5 μM of LY294002 or 10 μM of CQ for 2 days. a–d Proportion of Annexin V/PI-positive cells were analyzed and then presented in bar charts. e, f After treatment with T-DM1 in combination with autophagy inhibitors, the activation of caspase-3/7 was analyzed by commercial kit and presented in bar charts

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