Table 5 List of mutations of the genes other than HA in progeny strains
Gen | Tissue | Immunized | Nonimmunized |
|---|---|---|---|
NA | Trachea | Amino acids 67–76 deletion (20/20) | – |
Lung | Amino acids 67–76 deletion (24/24) | – | |
PB2 | Trachea | D256N (1/20), R318K (13/20), R355K (20/20) | R318K (19/19) |
Lung | R318K (19/24), R355K (24/24), K526R (1/24), A622V (2/24) | I63M (1/15), R318K (15/15) | |
PB1 | Trachea | I397V (1/20) | I517V (1/19) |
Lung | – | – | |
PA | Trachea | – | R185K (1/19), S190F (1/19), E533G (1/19), F646S (1/19), C693G (1/19) |
Lung | F46L (1/24), V127I (1/24), L132I (1/24), E319V (1/24) | V554I (1/15) | |
NP | Trachea | – | V186I (19/19), L466I (9/19) |
Lung | – | V186I (15/15), L466I (14/15) | |
NS | Trachea | – | L33Q (1/19), L77I (19/19) |
Lung | P85L (1/24) | L77I (15/15), V84M (1/15) | |
M1 | Trachea | L28P (1/20) | F62L (2/19), R256H (1/19) |
Lung | – | – | |
M2 | Trachea | – | – |
Lung | R304G (2/24) | A209T (1/15) |