Biotransformation of 5-hydroxymethylfurfural into 2,5-dihydroxymethylfuran by Ganoderma sessile and toxicological assessment of both compounds

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Table 1 Abnormal performance in behavioristics

Groups	Abnormal behaviours
A	None
B	During the first 30 min, all rats became quitter and slightly weaker than the control, and returned to normal within 1 h
C	During the first 30 min, all rats became quitter and slightly weaker than the control, and returned to normal within 1 h
D	Rat numbered 1 emerged convulsions, lethargy, convulsions, and limb weakness during the first 30 min, showed somnolence and decrease of animal heat in the next 30 min; others only behaved a quiet symptom, all rats returned to normal within 1 h
E	In the first 30 min, all rats were more active than control, then showed lethargic and dilatoriness, yet returned to normal after 30 min

Tables denoted the abnormal performance in behavioristics during the first 4 h of continuous observation, n = 6 of A, D and E groups, n = 3 of B and C groups. A: Distilled water (0 mg/kg); B: 5-HMF (300 mg/kg); C: DHMF (300 mg/kg); D: 5-HMF (2000 mg/kg); E: DHMF (2000 mg/kg)