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Fig. 6 | AMB Express

Fig. 6

From: Codon harmonization reduces amino acid misincorporation in bacterially expressed P. falciparum proteins and improves their immunogenicity

Fig. 6

N-PfCelTOS and CH-PfCelTOS induce comparable antibody and TH1 biased cellular responses. a Kinetic of PfCelTOS specific antibody responses, reported as antigen specific concentrations (µg/mL). Geometric means and 95% confidence interval are reported. b Scatter plot of individual mouse responses at 2 weeks post 3rd immunization reported as the mean and standard deviation. Statistical significance of differences in antibody responses induced by N-PfCelTOS and CH-PfCelTOS was determined using Parametric, two tailed, unpaired T-test (**p = 0.0214, *p = 0.00393 against PfCelTOS and C-terminus of PfCelTOS proteins, respectively). Splenocytes from individual mice were tested for secretion of IL-4 and IFN-γ cytokines by ELISpot. Data are reported as the mean plus standard error of the mean of cytokine producing cells (spot forming cells (SFC)/106 splenocytes) of individual mice (c) IL-4 and (d) IFN-γ

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