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Table 4 Minimum inhibitory concentration (MIC) of Berberis aristata extracts, its partially purified phytoconstituents (PPPs) and standard antibiotics

From: Scientific validation of the antimicrobial and antiproliferative potential of Berberis aristata DC root bark, its phytoconstituents and their biosafety

Microorganisms MIC (mg/mL)
Aqa EAb Alkaloids Flavonoids Diterpenes Gentamicin Chloramphenicol
SA 2.5 0.05 1 0.1 0.5 0.0002 0.01
SE 25 0.1 3 3 3 0.01 0.01
MRSA 5 0.05 5 0.1 0.05 0.005 0.01
EC 5 0.05 5 3 3 0.005 0.01
EF 22.5 0.1 ND 1 1 0.03 0.3
KP1 2.5 0.05 1 0.05 0.1 0.0002 0.01
KP2 ND 0.1 1 0.5 0.7 0.0005 0.001
SF ND 0.05 ND ND 5 0.005 0.01
ST1 ND 0.05 ND ND ND 0.005 0.1
ST2 15 0.05 1 0.05 0.1 0.0003 0.001
PA 5 0.05 10 10 0.05 0.005 0.7
CA 7.5 0.05 0.7 0.1 0.05 0.0003c ND
CT ND 0.5 ND 1 1 0.1c ND
  1. SA, Staphylococcus aureus; SE, Staphylococcus epidermidis; EC, Escherichia coli; KP1, Klebsiella pneumoniae 1; KP2, Klebsiella pneumoniae 2; SF, Shigella flexneri; ST1, Salmonella typhimurium 1; ST2, Salmonella typhimurium 2; PA, Pseudomonas aeruginosa; CA, Candida albicans; CT, Candida tropicalis; MRSA, methicillin-resistant Staphylococcus aureus; ND, not determined
  2. aAqueous extract
  3. bEthyl acetate extract
  4. cAmphotericin B