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Table 7 Minimum inhibitory concentration (MIC) and fractional inhibitory concentration (FIC) of aqueous extract, each antibiotic alone and their combination against MDR pathogenic bacterial isolates

From: Comprehensive investigation on the synergistic antibacterial activities of Jatropha curcas pressed cake and seed oil in combination with antibiotics

Strain Compound MICa (mg/mL)/MICb (µg/mL) FIC FICI Output
Alone Combined
MRSA1 Aq/Ctx –/100 50/25 –/0.25 ND ND
Aq/R –/100 1.56/0.78 –/0.007 ND ND
Aq/Of –/100 100/50 –/0.5 ND ND
Aq/Cip –/50 100/50 –/1 ND ND
Aq/Mox –/1.56 100/50 –/32 ND ND
MRSA2 Aq/Ctx –/100 100/50 –/0.5 ND ND
Aq/R –/3.125 0.78/0.39 –/0.1 ND ND
Aq/Of –/25 100/50 –/2 ND ND
Aq/Cip –/50 100/50 –/1 ND ND
Aq/Mox –/0.78 25/12.5 –/16 ND ND
MRSA3 Aq/Ctx 200/50 100/50 0.5/1 1.5 Indifference
Aq/R 200/3.13 0.39/0.195 0.001/0.06 0.06 Synergistic
Aq/Of 200/50 100/50 0.5/1 1.5 Indifference
Aq/Cip 200/12.5 100/50 2/4 6 Antagonistic
Aq/Mox 200/0.39 12.5/6.25 0.25/16 16.2 Antagonistic
MRSA4 Aq/Ctx –/50 100/50 –/1 ND ND
Aq/R –/3.125 100/50 –/16 ND ND
Aq/Of –/1.56 100/50 –/32 ND ND
Aq/Cip –/3.125 100/50 –/16 ND ND
Aq/Mox –/0.78 50/25 –/32 ND ND
MRSA5 Aq/Ctx 200/3.13 100/50 0.5/16 16.5 Antagonistic
Aq/R 200/3.13 6.25/3.125 0.03/1 1.03 Indifference
Aq/Of 200/100 12.5/6.25 0.03/0.06 0.09 Synergistic
Aq/Cip 200/50 12.5/6.25 0.06/0.1 0.18 Synergistic
Aq/Mox 200/1.56 6.25/3.125 0.06/2 2.0 Indifference
A. baumannii MDR Aq/Ctx –/6.25 100/50 –/8 ND ND
Aq/R –/3.125 0.78/0.39 –/0.1 ND ND
Aq/Of –/0.78 100/50 –/64 ND ND
Aq/Cip –/6.25 100/50 –/8 ND ND
Aq/Mox –/1.56 6.25/3.125 –/2 ND ND
Klebsiella pneumoniae Aq/Ctx –/100 100/50 –/0.5 ND ND
Aq/R –/100 100/50 –/0.5 ND ND
Aq/Of –/25 100/50 –/2 ND ND
Aq/Cip –/50 100/50 –/1 ND ND
Aq/Mox –/1.56 12.5/6.25 –/4 ND ND
P. chlororaphis Aq/Ctx –/– –/– –/– ND ND
Aq/R –/100 100/50 –/0.5 ND ND
Aq/Of –/6.25 50/25 –/4 ND ND
Aq/Cip –/3.125 50/25 –/8 ND ND
Aq/Mox –/1.56 6.25/3.125 –/2 ND ND
P. monteilii Aq/Ctx –/100 100/50 –/0.5 ND ND
Aq/R –/– 1.56/0.78 –/– ND ND
Aq/Of –/100 1.56/0.78 –/0.007 ND ND
Aq/Cip –/50 0.78/0.39 –/0.007 ND ND
Aq/Mox –/0.78 100/50 –/64 ND ND
  1. MICa minimal inhibitory concentration for aqueous extract when applied alone, MICb minimal inhibitory concentration for antibiotic when applied alone, Me methanolic extract, Ctx cefotaxime, R rifampicin, Of ofloxacin, Cip ciprofloxacin, Mox moxifloxacin, ND not determined