Table 1 Minimum inhibitory concentration (MIC) and fractional inhibitory concentration (FIC) of methanolic extract and each antibiotic and their combination against clinical pathogenic and reference bacterial isolates

A. baumannii

Me/Ctx

100/0.19

0.39/0.195

0.0039/1

1.0

Indifference

Me/R

100/12.5

12.5/0.39

0.125/0.031

0.15

Synergistic

Me/Of

100/12.5

12.5/6.25

0.125/0.5

0.6

Indifference

Me/Cip

100/6.25

12.5/6.25

0.125/1

1.12

Indifference

Me/Mox

100/6.25

6.25/3.125

0.0625/0.5

0.5

Synergistic

E. coli

Me/Ctx

100/100

100/50

1/1

2.0

Indifference

Me/R

100/100

1.56/0.78

0.0625/0.0156

0.0781.0

Synergistic

Me/Of

100/50

0.39/3.125

0.0039/0.0625

0.06

Synergistic

Me/Cip

100/100

6.25/0.195

0.0625/0.0039

0.0664

Synergistic

Me/Mox

100/3.125

25/12.5

0.25/8.01

4.25

Antagonistic

E. faecalis

Me/Ctx

100/50

100/50

1/1

2.0

Indifference

Me/R

100/100

6.25/3.125

0.0625/0.031

0.09

Synergistic

Me/Of

100/12.5

25/0.39

0.25/0.0312

0.28

Synergistic

Me/Cip

100/50

0.78/12.5

0.0078/0.25

0.25

Synergistic

Me/Mox

100/1.56

25/12.5

0.25/8.01

8.26

Antagonistic

P. vulgaris

Me/Ctx

100/0.19

12.5/6.25

0.125/32.05

32.17

Antagonistic

Me/R

100/6.25

12.5/6.25

0.125/1

1.125

Indifference

Me/Of

100/12.5

12.5/3.125

0.125/0.25

0.375

Synergistic

Me/Cip

100/6.25

6.25/6.25

0.0625/1

1.062

Indifference

Me/Mox

100/6.25

100/50

1/8

8.26

Antagonistic

S. aureus

Me/Ctx

100/50

0.78/0.39

0.0078/0.0078

0.0156

Synergistic

Me/R

100/6.25

0.39/0.195

0.0039/0.0312

0.0351

Synergistic

Me/Of

100/50

0.39/1.56

0.0039/64.10

64.106

antagonistic

Me/Cip

100/12.5

3.125/0.39

0.0312/0.0312

0.062

Synergistic

Me/Mox

100/3.125

3.125/1.56

0.0312/0.49

0.53

Synergistic

P. aeruginosa

Me/Ctx

100/50

50/3.125

0.06/0.06

0.1

Synergistic

Me/R

100/6.25

100/1.56

0.03/0.2

0.2

Synergistic

Me/Of

100/12.5

25/50

0.003/4

4.0039

Antagonism

Me/Cip

100/3.125

100/0.39

1/0.1

1.1

Indifference

Me/Mox

100/0.39

25/3.125

0.06/8

8

Antagonistic

S. aureus (ATCC)

Me/Ctx

50/50

0.78/0.39

0.008/256

0.023

Synergistic

Me/R

50/6.25

0.39/0.195

0.007/0.03

0.03

Synergistic

Me/Of

50/3.125

0.39/0.195

0.007/0.06

0.07

Synergistic

Me/Cip

50/1.56

1.56/0.78

0.03/0.5

0.5

Synergistic

Me/Mox

50/0.78

12.5/6.25

0.12/8

8.12

Antagonistic

E. coli (ATCC)

Me/Ctx

100/0.78

0.78/0.39

0.007/0.5

0.5

Synergistic

Me/R

100/6.25

1.56/0.78

0.01/0.12

0.1

Synergistic

Me/Of

100/3.125

0.097/0.048

0.0009/0.01

0.01

Synergistic

Me/Cip

100/3.125

0.78/0.39

0.007/0.12

0.1

Synergistic

Me/Mox

100/0.39

12.5/6.25

0.12/16

16

Antagonistic