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Table 1 Minimum inhibitory concentration (MIC) and fractional inhibitory concentration (FIC) of methanolic extract and each antibiotic and their combination against clinical pathogenic and reference bacterial isolates

From: Comprehensive investigation on the synergistic antibacterial activities of Jatropha curcas pressed cake and seed oil in combination with antibiotics

Strain Compound MICa (mg/mL)/MICb (µg/mL) FIC FICI Output
Alone Combined
A. baumannii Me/Ctx 100/0.19 0.39/0.195 0.0039/1 1.0 Indifference
Me/R 100/12.5 12.5/0.39 0.125/0.031 0.15 Synergistic
Me/Of 100/12.5 12.5/6.25 0.125/0.5 0.6 Indifference
Me/Cip 100/6.25 12.5/6.25 0.125/1 1.12 Indifference
Me/Mox 100/6.25 6.25/3.125 0.0625/0.5 0.5 Synergistic
E. coli Me/Ctx 100/100 100/50 1/1 2.0 Indifference
Me/R 100/100 1.56/0.78 0.0625/0.0156 0.0781.0 Synergistic
Me/Of 100/50 0.39/3.125 0.0039/0.0625 0.06 Synergistic
Me/Cip 100/100 6.25/0.195 0.0625/0.0039 0.0664 Synergistic
Me/Mox 100/3.125 25/12.5 0.25/8.01 4.25 Antagonistic
E. faecalis Me/Ctx 100/50 100/50 1/1 2.0 Indifference
Me/R 100/100 6.25/3.125 0.0625/0.031 0.09 Synergistic
Me/Of 100/12.5 25/0.39 0.25/0.0312 0.28 Synergistic
Me/Cip 100/50 0.78/12.5 0.0078/0.25 0.25 Synergistic
Me/Mox 100/1.56 25/12.5 0.25/8.01 8.26 Antagonistic
P. vulgaris Me/Ctx 100/0.19 12.5/6.25 0.125/32.05 32.17 Antagonistic
Me/R 100/6.25 12.5/6.25 0.125/1 1.125 Indifference
Me/Of 100/12.5 12.5/3.125 0.125/0.25 0.375 Synergistic
Me/Cip 100/6.25 6.25/6.25 0.0625/1 1.062 Indifference
Me/Mox 100/6.25 100/50 1/8 8.26 Antagonistic
S. aureus Me/Ctx 100/50 0.78/0.39 0.0078/0.0078 0.0156 Synergistic
Me/R 100/6.25 0.39/0.195 0.0039/0.0312 0.0351 Synergistic
Me/Of 100/50 0.39/1.56 0.0039/64.10 64.106 antagonistic
Me/Cip 100/12.5 3.125/0.39 0.0312/0.0312 0.062 Synergistic
Me/Mox 100/3.125 3.125/1.56 0.0312/0.49 0.53 Synergistic
P. aeruginosa Me/Ctx 100/50 50/3.125 0.06/0.06 0.1 Synergistic
Me/R 100/6.25 100/1.56 0.03/0.2 0.2 Synergistic
Me/Of 100/12.5 25/50 0.003/4 4.0039 Antagonism
Me/Cip 100/3.125 100/0.39 1/0.1 1.1 Indifference
Me/Mox 100/0.39 25/3.125 0.06/8 8 Antagonistic
S. aureus (ATCC) Me/Ctx 50/50 0.78/0.39 0.008/256 0.023 Synergistic
Me/R 50/6.25 0.39/0.195 0.007/0.03 0.03 Synergistic
Me/Of 50/3.125 0.39/0.195 0.007/0.06 0.07 Synergistic
Me/Cip 50/1.56 1.56/0.78 0.03/0.5 0.5 Synergistic
Me/Mox 50/0.78 12.5/6.25 0.12/8 8.12 Antagonistic
E. coli (ATCC) Me/Ctx 100/0.78 0.78/0.39 0.007/0.5 0.5 Synergistic
Me/R 100/6.25 1.56/0.78 0.01/0.12 0.1 Synergistic
Me/Of 100/3.125 0.097/0.048 0.0009/0.01 0.01 Synergistic
Me/Cip 100/3.125 0.78/0.39 0.007/0.12 0.1 Synergistic
Me/Mox 100/0.39 12.5/6.25 0.12/16 16 Antagonistic
  1. MICa minimal inhibitory concentration for methanolic extract when applied alone, MICb minimal inhibitory concentration for antibiotic when applied alone, Me methanolic extract, Ctx cefotaxime, R rifampicin, Of ofloxacin, Cip ciprofloxacin, Mox moxifloxacin, ND not determined