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Table 1 Antigenic regions, their positions, and sequences of E. coli, Erwinia chrysanthemi, and Bacillus licheniformis l-asparaginases

From: Experimental and bioinformatics study for production of l-asparaginase from Bacillus licheniformis: a promising enzyme for medical application

E. coli l-asparaginase (348 aa)
Accession # D6JF83a
Erwinia chrysanthemi l-asparaginase (348 aa)
Accession # P06608b
Bacillus licheniformis l-asparaginase (322 aa)
Accession # P30363c
Antigenic region Start End Sequence Anti-genic region Start End Sequence Anti-genic region Start End Sequence
1 323 333 KARVLLQLALT 1 6 20 KSLFVLVLFFVFTS 1 195 216 KRDVHQLQRPLPAVDIVKCYLD
2 224 243 PFDVSKLNELPKVGIVYNYA 2 121 142 ESAYFLHLTVKSDKPVVFVAAM 2 304 314 KLAVLLASYKE
3 245 257 ASDLPAKALVDG 3 88 101 GDVVLKLSQRVL 3 256 265 NQGVYIVITT
4 118 135 AYFLDLTVKCDKPVVMVG 4 290 297 KGVVVIRS 4 128 140 NIRHAVYTACSPD
5 6 16 KTALAALVMGF 5 156 165 LLEAVRVAGD 5 184 193 NDKVYVYQKP
6 165 174 NRGVLVVMND 6 311 333 LPGLVSDSLNPAHARILLMLALT 6 144 152 AGTVVVFNE
7 49 70 AGKVGVENLVNAVPQLKDIANV 7 22 34 ADKLPNIVILATG 7 35 58 AEMCSLPEDVQIDVYPAFQLPSMH
8 151 159 LYNAVVTAA 8 172 179 GVMVVLND 8 106 114 ERPVVVTGS
9 286 298 GTAVVRSSRVPTG 9 107 114 VDGVVITH 9 157 168 ARYVKKVHASNL
10 72 79 EQVVNIG 10 251 270 PEYLYDAAIQHGVKGIVYAG 10 231 237 EGIVLEG
11 190 204 VATFKSVNYGPLGYI 11 226 248 TRSVFDVRGLTSLPKVDILYGYQ 11 170 181 GFDVFGFGYLGI
12 259 265 DGIVSAG 12 205 214 YLGVIIGNRI 12 95 102 TAYFLDLT
13 88 94 WLTLAKK 13 52 73 AGALGVDTLINAVPEVKKLANV 13 60 68 TFEHLLELK
14 18 32 GAALALPNITILAG 14 337 345 DPKVIQEYF 14 81 87 DGAVVTH
15 272 282 YKTVFDTLATA 15 274 281 GSVSVRGI 15 4 9 KVALIT
16 311 317 YGFVASG 16 303 309 GIVPPDE 16 278 294 YAGSSYDLAKKGVILGK
17 339 345 QQIQQIF      17 24 29 LAAGAI
18 104 109 GFVITH         
  1. aE. coli FDA approved l-asparaginase (marketed under the brand name Elspar)
  2. bErwinia chrysanthemi (Dickeya chrysanthemi or Pectobacterium chrysanthemi) l-asparaginase (marketed under the brand name Erwinaze)
  3. cBacillus licheniformis l-asparaginase