Antimicrobial potential of toothpaste formulated from extracts of Syzygium aromaticum, Dennettia tripetala and Jatropha curcas latex against some oral pathogenic microorganisms

Oluwasina, Olugbenga Oludayo; Ezenwosu, Ifunanya Vivian; Ogidi, Clement Olusola; Oyetayo, Victor Olusegun

doi:10.1186/s13568-019-0744-2

AMB Express

Table 4 Zones of inhibition displayed by the formulated pastes against tested microorganisms at 20 mg/mL

From: Antimicrobial potential of toothpaste formulated from extracts of Syzygium aromaticum, Dennettia tripetala and Jatropha curcas latex against some oral pathogenic microorganisms

Toothpaste	E. coli	Bacillus sp.	S. aureus	S. epidermidis	M. luteus	S. mutans	C. albicans	S. pyogenes	L. acidophilus	MRSA	S. aureus (ATCC 29213)	P. aeruginosa (ATCC 27853)	E. coli (ATCC 35218)
DenSyzJat	13.8^e ± 0.58	10.00^cd ± 0.00	18.00^d ± 0.0	14.00^e ± 0.00	17.7^g ± 0.6	17.67^d ± 0.58	16.30^e± 0.0	10.70^c ± 0.01	18.30^f ± 0.02	13.90^d ± 0.58	15.00^e ± 0.0	11.30^cd ± 0.58	12.80^d ± 0.05
DenSyz	8.00^c ± 0.00	8.33^c ± 0.58	14.67^c ± 0.58	10.83^d ± 0.06	10.00^d ± 0.00	9.27^b ± 0.30	10.30^c ± 0.0	7.30^b ± 0.0	13.30^d ± 0.03	10.00^c ± 0.0	11.00^d ± 0.0	9.70^c ± 0.04	9.00^c ± 0.03
SyzJat	10.00^d ± 0.00	9.00^c ± 0.02	15.67^c ± 0.26	10.67^d ± 0.06	13.00^e ± 0.02	12.00^c ± 0.02	12.00^d ± 0.0	9.30^c ± 0.0	16.00^e ± 0.0	10.00^c ± 0.0	13.10^e ± 0.00	10.00^c ± 0.0	11.30^d ± 0.56
DenJat	5.00^b ± 0.01	0.00^a	0.00^a	8.33^c ± 0.58	15.00^f ± 0.00	0.00^a	14.40^d ± 0.0	0.0^a	12.70^d ± 0.01	9.80^c ± 0.0	9.30^c ± 0.00	0.0^a	8.80^c ± 0.02
Syz	6.67^b,c ± 0.58	0.00^a	14.00^c ± 0.00	10.30^d ± 0.58	0.00^a	7.67^b ± 0.58	6.00^b ± 0.0	6.30^b ± 0.0	8.40^c ± 0.02	7.30^b ± 0.53	0.0^a	7.00^b ± 0.0	8.60^c ± 0.54
Den	0.00^a	0.00^a	0.00^a	0.00^a	4.33^b ± 0.58	0.00^a	6.00^b ± 0.0	0.0^a	8.00^c ± 0.0	0.0^a	6.70^b ± 0.00	0.0^a	0.0a
Jat	4.00^b ± 0.0	4.67^b ± 0.58	7.33^b ± 0.58	0.00a	8.33^c ± 0.58	0.00^a	8.70^c ± 0.2	6.60^b ± 0.0	10.00^d ± 0.0	8.00^b ± 0.0	0.0^a	7.33^b ± 0.0	6.00^b ± 0.00
Com A	0.00^a	0.00^a	6.67^b ± 0.58	6.00^b ± 0.00	4.00^b ± 0.00	0.00^a	5.00^b ± 0.0	0.0^a	5.00^b ± 0.0	0.0^a	5.00^b ± 0.02	0.0^a	0.0^a
Com B	0.00^a	0.00^a	6.67^b ± 0.19	6.00^b ± 0.19	4.00^b ± 0.19	0.00^a	4.80^b ± 0.0	0.0^a	5.00^b ± 0.0	0.0^a	4.60^b ± 0.02	0.0^a	5.30^b ± 0.02
Com C	0.00^a	0.00^a	0.00^a	0.00^a	0.00^a	0.00^a	0.0^a	0.0^a	0.0^a	0.0^a	0.0^a	0.0^a	0.0^a
Flucloxacillin^a	16.00^f ± 0.00	8.00^c ± 0.00	14.67^c ± 0.58	21.00^f ± 0.00	18.00^g ± 0.20	16.78^d ± 0.49	21.30^f ± 0.0	12.3 ± 0.02^d	16.60^e ± 0.0	15.1 ± 0.0^d	14.00^e ± 0.0	7.60^b ± 0.02	10.30^cd ± 0.24
Glycerin	0.00^a	0.00^a	0.00^a	0.00^a	0.00^a	0.00^a	0.0^a	0.0^a	0.0^a	0.0^a	0.0^a	0.0^a	0.0^a
Distilled water	0.00^a	0.00^a	0.00^a	0.00^a	0.00^a	0.00^a	0.0^a	0.0^a	0.0^a	0.0^a	0.0^a	0.0^a	0.0^a

Values are mean ± SD of replicates (n = 3), means with different letters within a column are significantly different by Duncan (P < 0.05)
DenSyzJat-(Triarotex)—Dennettia tripetala, Syzygium aromaticum, and Jatropha curcas latex
DenSyz-(Triaro)—Dennettia tripetala and Syzygium aromaticum as the active ingredients
SyzJat(Arotex)—Syzygium aromaticum and Jatropha curcas latex as active ingredients
DenJat-(Tritex)—Dennettia tripetala and Jatropha curcas latex
Syz-(Aro)—Syzygium aromaticum mixture
Den-(Tri)—Dennettia tripetala
Jat-(Tex)—Jatropha curcas latex
Placebo-without plant extracts material
Commercial fluoride toothpaste—Com A
Commercial herbal toothpaste—Com B
Commercial ordinary toothpaste—Com C
^aYeast was tested against ketoconazole

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