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Fig. 2 | AMB Express

Fig. 2

From: Folate promotes S-adenosyl methionine reactions and the microbial methylation cycle and boosts ruminants production and reproduction

Fig. 2

Metabolism of folate and its relationship with methionine. The key donor (SAM) is synthesized from methionine and is used to transfer a methyl group in DNA and the protein methylation cycle. Once a methyl group is transferred, it will change into S-adenosyl homocysteine, which further becomes homocysteine, and then methionine. Methyltetrahydrofolate (THF) and vitamin B12 are required as key regulatory cofactors. FAD, flavin adenine dinucleotide; NADPH, nicotinamide adenine dinucleotide phosphate

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