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Table 1 MIC and MBC assays of NZ2114 and ampicillin to S. suis, S. aureus, S. pneumonia, and E. coil

From: In vitro and in vivo antibacterial effect of NZ2114 against Streptococcus suis type 2 infection in mice peritonitis models

Strains Source MIC (μM) MBC (μM)
NZ2114 Ampicillin NZ2114 Ampicillin
S. suis CVCC606 CVCCa 0.03 0.17 0.03 0.34
S. suis CVCC3309 CVCC 0.03 0.34 0.06 0.34
S. suis CVCC3928 CVCC 0.06 0.34 0.06 1.02
S. aureus ATCC25923 CVCC 0.03 1.35 0.06 1.35
S. aureus ATCC6538 CGMCCb 0.11 1.35 0.11 2.69
S. aureus ATCC43300 CGMCC 0.9 10.78 0.9 21.56
Streptococcus pneumoniae CGMCC1.8722 CGMCC 0.45 1.35 0.9 2.69
S. pneumoniae CVCC2350 CVCC 0.9 2.69 1.8 5.38
S. pneumoniae CVCC31968 CVCC 0.9 2.69 0.9 2.69
E.coli CVCC195 CVCC ≥29.09 0.31 ≥29.09 0.31
E.coli CVCC1515 CVCC ≥29.09 NT ≥29.09 NT
  1. NT no tested
  2. aChina Institute of Veterinary Drug Control
  3. bChina General Microbiological Culture Collection Center