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Table 3 Twelve trial Plackett Burman design matrix for the experimental variables with coded values for melanin production

From: Improved production of melanin from Aspergillus fumigatus AFGRD105 by optimization of media factors

Runs

Experimental parameter

Response (mg/L)

1

2

3

4

5

6

7

8

9

10

11

1

−1

−1

+1

−1

+1

+1

−1

+1

+1

+1

−1

15.6

2

−1

−1

−1

+1

−1

+1

+1

−1

+1

+1

+1

16.7

3

−1

+1

+1

−1

+1

+1

+1

−1

−1

−1

+1

17.5

4

+1

−1

+1

+1

+1

−1

−1

−1

+1

−1

+1

11.8

5

−1

−1

−1

−1

−1

−1

−1

−1

−1

−1

−1

19.8

6

+1

+1

−1

+1

+1

+1

−1

−1

−1

+1

−1

17.6

7

+1

−1

+1

+1

−1

+1

+1

+1

−1

−1

−1

16.7

8

+1

−1

−1

−1

+1

−1

+1

+1

−1

+1

+1

12.3

9

+1

+1

+1

−1

−1

−1

+1

−1

+1

+1

−1

14.5

10

−1

+1

−1

+1

+1

−1

+1

+1

+1

−1

−1

18.9

11

+1

+1

−1

−1

−1

+1

−1

+1

+1

−1

+1

14.9

12

−1

+1

+1

+1

−1

−1

−1

+1

−1

+1

+1

12.3