Nitric oxide diffusion in CNC. MAHMA NONOate was mixed with cellulose nanocrystals (whisker type) and a hydrogel was formed with a final concentration of 1 mM. A microcapilary was tapered with a tip diameter of ca. 10 μm using a glass puller. Consequently the hydrogel–NONOate was injected into the microcapillary and the microcapillary was placed into a phosphate buffer solution (PBS). A nitric oxide microsensor was immediately used to measure release of NO (both concentration and flux). a Nitric oxide concentration profiles from the hydrogel surface. b Nitric oxide flux profiles. 10:1 represent a 10 times dilution of the MAHMA NONOate dissolved in CNC. Error bars represent the standard error of three replicas.