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Table 3 Microbicidal effect of CEN1 HC against Gram-positive and Gram-negative bacterial strains and a yeast strain

From: Anti-infectious and anti-inflammatory effects of peptide fragments sequentially derived from the antimicrobial peptide centrocin 1 isolated from the green sea urchin, Strongylocentrotus droebachiensis

  CEN1 HC MMC99(mg/L) fusidic acid MMC99(mg/L) mupirocin MMC99(mg/L)
Microorganism, strain 0.037% BHI 50% h.i. SWF 0.037% BHI 50% h.i. SWF 0.037% BHI 50% h.i. SWF
S. aureus ATCC 12600 6.3 12.5 6.3 6.3 3.1 3.1
MRSA ATCC 33591 6.3 25 6.3 6.3 3.1 3.1
S. pyogenes ATCC 12344 3.1 50 >200 >200 6.3 3.1
S. epidermidis ATCC 12228 3.1 12.5 6.3 6.3 3.1 3.1
P. acnes ATCC 6919 6.3 12.5 nd nd >200 >200
E. coli ATCC 11775 6.3 25 >200 >200 >200 >200
P. aeruginosa ATCC 15442 6.3 100 >200 >200 >200 >200
K. pneumoniae CCUG 59413 3.1 12.5 >200 >200 >200 >200
A. baumannii CCUG 58437 3.1 6.3 >200 >200 >200 >200
C. albicans ATCC 64549 6.3 >200 >200 >200 >200 >200
  1. The substances were tested using a MMC99 SSassay in concentrations up to 200 mg/L in 0.037% BHI or 50% h.i. SWF. Peptides were added to bacterial cells in duplicate (n = 2). Data are presented as maximum values from at least two independent experiments. h.i. = heat inactivated, nd = not determined.