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Table 3 Microbicidal effect of CEN1 HC against Gram-positive and Gram-negative bacterial strains and a yeast strain

From: Anti-infectious and anti-inflammatory effects of peptide fragments sequentially derived from the antimicrobial peptide centrocin 1 isolated from the green sea urchin, Strongylocentrotus droebachiensis

 

CEN1 HC MMC99(mg/L)

fusidic acid MMC99(mg/L)

mupirocin MMC99(mg/L)

Microorganism, strain

0.037% BHI

50% h.i. SWF

0.037% BHI

50% h.i. SWF

0.037% BHI

50% h.i. SWF

S. aureus ATCC 12600

6.3

12.5

6.3

6.3

3.1

3.1

MRSA ATCC 33591

6.3

25

6.3

6.3

3.1

3.1

S. pyogenes ATCC 12344

3.1

50

>200

>200

6.3

3.1

S. epidermidis ATCC 12228

3.1

12.5

6.3

6.3

3.1

3.1

P. acnes ATCC 6919

6.3

12.5

nd

nd

>200

>200

E. coli ATCC 11775

6.3

25

>200

>200

>200

>200

P. aeruginosa ATCC 15442

6.3

100

>200

>200

>200

>200

K. pneumoniae CCUG 59413

3.1

12.5

>200

>200

>200

>200

A. baumannii CCUG 58437

3.1

6.3

>200

>200

>200

>200

C. albicans ATCC 64549

6.3

>200

>200

>200

>200

>200

  1. The substances were tested using a MMC99 SSassay in concentrations up to 200 mg/L in 0.037% BHI or 50% h.i. SWF. Peptides were added to bacterial cells in duplicate (n = 2). Data are presented as maximum values from at least two independent experiments. h.i. = heat inactivated, nd = not determined.