Table 4 Cytotoxic effect of the ethyl acetate extract of A. terreus and pure compounds (1–4) on RAW 264.7 cells and anti-inflammatory activity of the ethyl acetate extract of A. terreus and pure compounds (1–2, 4)
From: Bioactive metabolites identified from Aspergillus terreus derived from soil
Tested samples | IC50 (µg/mL) mean ± SD | IL-6 (pg/mL), mean ± SD | TNF-α (pg/mL) mean ± SD |
|---|---|---|---|
Ethyl acetate extract | 1215 ± 68.2 | 88.35 ± 0.92*** | 122.50 ± 3.98*** |
1 | 858 .0 ± 48.2 (1287.3 µM) | 51.63 ± 2.79*** | 68.220 ± 3.09*** |
2 | 718.7 ± 40.4 (1694.4 µM) | 37.25 ± 0.87*** | 87.97 ± 6.7*** |
3 | 246.8 ± 13.9 (560.7 µM) | – | – |
4 | 449.0 ± 25.2 (797.3 µM) | 129.00 ± 1.77*** | 268.30 ± 3.43*** |
LPS control |  | 227.50 ± 29.2 | 452.5 0 ± 46.1 |