Production of ginsenoside compound K from American ginseng extract by fed-batch culture of Aspergillus tubingensis

AMB Express

Table 2 Effect of feeding period during continuous feeding of American ginseng extract (age) in fed-batch fermentation on the concentration, yields, productivity, and molar conversion of C-K for the biotransformation of AGE into C-K

No	F_start (h)	F_stop (h)	C-K_max (g/L)	Y_P/S (g/g)	Y_P/AGE (g/g)	q_P (mg/L/h)	Molar conversion (%)	f_t (h)
1	6	132	2.72 ± 0.02	0.05 ± 0.001	0.17 ± 0.001	17.4 ± 0.14	70.8 ± 0.57	156
2	12	132	3.31 ± 0.06	0.06 ± 0.001	0.20 ± 0.004	21.2 ± 0.38	86.2 ± 1.56	156
3	18	132	2.93 ± 0.05	0.05 ± 0.001	0.18 ± 0.003	18.8 ± 0.32	76.3 ± 1.29	156
4	24	132	2.83 ± 0.05	0.05 ± 0.001	0.18 ± 0.003	18.2 ± 0.32	73.7 ± 1.29	156
5	36	132	2.63 ± 0.04	0.04 ± 0.004	0.16 ± 0.002	16.9 ± 0.23	68.5 ± 0.95	156
6	12	60	2.77 ± 0.03	0.05 ± 0.001	0.17 ± 0.002	19.2 ± 0.18	72.1 ± 0.68	144
7	12	84	3.47 ± 0.05	0.06 ± 0.001	0.22 ± 0.003	24.1 ± 0.33	90.4 ± 1.24	144
8	12	108	3.41 ± 0.07	0.06 ± 0.001	0.21 ± 0.004	21.8 ± 0.45	88.8 ± 1.83	156
9	12	120	3.35 ± 0.02	0.06 ± 0.001	0.21 ± 0.001	21.4 ± 0.13	87.2 ± 0.53	156
10	12	132	3.31 ± 0.06	0.06 ± 0.001	0.20 ± 0.004	21.2 ± 0.39	86.2 ± 1.59	156