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Fig. 2 | AMB Express

Fig. 2

From: Angiogenic inhibitors delivered by the type III secretion system of tumor-targeting Salmonella typhimurium safely shrink tumors in mice

Fig. 2

The conversion of obligate anaerobic strain ST4 to ST8 could target the viable regions inside solid tumor and prevent the bacterial killing of the mice. a Distribution and tumor colonization of ST4, ST7 and ST8 in tumor-bearing nude mice. Different organs were collected at 14 days after bacterial infection and analyzed for the presence of bacteria (ND stands for CFU = 0). Shown is the mean CFU per gram tissues plus SD. b Representative histopathologic and immunohistochemical staining of Salmonella on liver sections as indicated. Scale bar 100 μm. Necrotic region was marked by N. c Representative histopathologic and immunohistochemical detection of Salmonella identified macroscopic regions of the viable region (marked with V), necrotic area (marked with N) and bacterial colonization. Scale bar 500 μm

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