Isolation, purification and characterization of novel antimicrobial compound 7-methoxy-2,2-dimethyl-4-octa-4′,6′-dienyl-2H-napthalene-1-one from Penicillium sp. and its cytotoxicity studies

AMB Express

Table 1 Result of Box–Benhken design experiment for antimicrobial activity of Penicillium sp

Std.	Dextrose	Starch	Yeast extract	S. aureus	S. epidermidis	K. pneumoniae	C. albicans	MRSA
Std.	(g/100 mL)			Zone of inhibition (mm)
1	0.5	0.5	0.5	15	17	14	17	15
2	0.5	2	0.5	27	28	16	17	18
3	2	0.5	0.5	20	17	14	17	17
4	2	2	0.5	34	36	28	32	27
5	1.25	0.5	0.2	20	20	15	16	17
6	1.25	2	0.2	40	41	30	34	30
7	1.25	0.5	0.8	21	25	16	18	18
8	1.25	2	0.8	30	32	18	18	18
9	0.5	1.25	0.2	30	30	14	17	15
10	2	1.25	0.2	25	26	16	18	17
11	0.5	1.25	0.8	22	20	15	16	17
12	2	1.25	0.8	25	20	16	17	18
13	1.25	1.25	0.5	33	34	16	17	16
14	1.25	1.25	0.5	30	28	17	17	17
15	1.25	1.25	0.5	32	33	16	18	17
16	1.25	1.25	0.5	35	33	16	18	16
17	1.25	1.25	0.5	32	33	16	17	16