Fig. 6
Coevolution of lanthipeptide leader and synthetase in a phylum-dependent manner. A Pairwise dN/dS distribution of lanthipeptide leader and lanM from actinobacteria (13 BGCs of roseocin family) and cyanobacteria phylum (9 BGCs) showed variation in different phyla suggesting coevolution of the lanthipeptide leader and synthetases. B Standard box plot of the evolutionary rates of CCG motif prochlorosin family LanMs (Cubillos-Ruiz et al. 2017) (Additional file 1: Table S3) and CHG motif LanMs of cyanobacteria (from the current study) showed a similar pattern (median 0.21 and 0.24, respectively), while the CHG motif lanMs of roseocin family in actinobacteria has a higher value (median 0.48). In the standard box plot, the lower and upper shows the first and third quartile values, respectively, separated by the median value. The error bar plots the minimum and maximum values. C Phylogenetic tree of CCG motif ProcMs (Cubillos-Ruiz et al. 2017) and CHG motif LanMs of cyanobacteria and actinobacteria (from current study). Prochlorosin family LanMs displayed significant divergence from CHG motif LanMs of cyanobacteria and actinobacteria