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Fig. 2 | AMB Express

Fig. 2

From: Phylogeny-guided genome mining of roseocin family lantibiotics to generate improved variants of roseocin

Fig. 2

Phylogenetic tree of 42 selected RosM homologs showed conservation of gene locus and characteristic features along the phylogenetic tree. Roseocin family constituted the BGCs from actinobacteria, having three types of BGCs’ organization (type 1–3), each forming a separate subclade. CHG motif LanM for processing of NHLP type leader sequence was found in all the BGCs except in a subclade of cyanobacteria (Synechocystis sp. PCC 7509 and C. minutus) where conservation of two types of LanMs (CHG and CCG motif) and two types of leader sequence (NHLP and N11P) were found in a single BGC. LanMs from the BGCs of Halorussus genus were placed in the root. Value from 500 replicates bootstrap test is indicated on each branch. The numbers given in the bracket are the number of members of that particular subclade. NHLP nitrile hydratase leader peptide, N11P Nif11 derived peptides

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