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AMB Express

Table 6 Antibacterial activity of Sephadex LH20 and Semi-prep RP-HPLC fractions against S. aureus

From: Bioassay-guided isolation and characterization of lead antimicrobial compounds from Acacia hydaspica plant extract

Samples

Sephadex LH20

MIC50 (µg/ml)

% GI

AHB/LH20-F3

53.1 ± 0.41

78.3 ± 0.65

AHB/LH20-F4

17.1 ± 0.20+++

90.0 ± 0.87*

AHB/LH20-F5

55.2 ± 0.58

76.6 ± 0.81

AHB/LH20-F6

64.9 ± 0.61

70.2 ± 0.92

Samples

Semi-prep RP-HPLC

MIC50 (µg/ml)

% GI

AHB/RP-HPLC-F5 (CG)

10.1 ± 0.11

92.0 ± 0.85*

Tetracyline

–

96.0 ± 1.01

  1. Values are expressed as mean ± SEM (n = 3). Symbol (–) indicated not done, MIC50 denoted the minimum inhibitory concentration resulting in 50% growth inhibition in µg/ml and GI represents growth inhibition at 100 µg/ml. *Indicate highest growth inhibitory potential (GI %) of fraction, and fraction with * activity was subjected for further testing to get MIC50 values and structure elucidation. +++Indicated significant (p < 0.0001) inhibitory potential of selected fraction compared to other fractions. Data were analyzed by one-way ANOVA followed by Tukey’s multiple comparison test
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