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AMB Express

Table 3 Antibacterial and antifungal activity of VLC-AHE fractions (% growth inhibition)

From: Bioassay-guided isolation and characterization of lead antimicrobial compounds from Acacia hydaspica plant extract

Antibacterial activity

Fractions

S. aureus

E. coli

P. aeruginosa

E. faecalis

K. pneumoniae

A. baumannii

B. subtilis

AHE/F4

46 ± 0.55

54 ± 0.48*

22 ± 0.23

13.2 ± 0.12

10 ± 0.11

7 ± 0.15

70 ± 0.87*

AHE/F5

43 ± 0.47

58 ± 0.53*

27.1 ± 0.20

11.7 ± 0.23

8 ± 0.27

9 ± 0.20

65 ± 0.76*

AHE/F6

40 ± 0.51

55 ± 0.61*

25.5 ± 0.41

15.2 ± 0.16

9.5 ± 0.11

8 ± 0.27

69 ± 0.77*

Tetracyclin

94 ± 1.01

95 ± 0.99

95 ± 1.03

–

93 ± 0.89

95 ± 1.15

96 ± 1.08

Penicillin G

–

–

–

94 ± 0.87

–

–

–

Antifungal activity

Fractions

C. neoformans

C. albicans

F. solani

A. niger

AHE/F4

11.29 ± 0.56

34.7 ± 0.73

75.6 ± 0.89*

63.2 ± 1.01

AHE/F5

10.92 ± 0.43

32.7 ± 0.59

73.6 ± 0.91*

71.7 ± 0.96*

AHE/F6

9.35 ± 0.28

31.6 ± 0.46

75.5 ± 0.69*

65.2 ± 0.79

Amphotericin B

94.9 ± 1.05

82.70 ± 0.93

90.1 ± 0.92

92.4 ± 1.01

  1. Values are expressed as mean ± SEM (n = 3). Significant activity = more than 70% growth inhibition; Good activity = 60–70% growth inhibition; Moderate activity = 50–60% growth inhibition; non-significant below 50% growth inhibition. *Indicate highest growth inhibitory potential (GI %) of fraction, and fractions with * activity were mixed and subjected for further purification and isolation of active metabolite bioactive against specific microbial strain
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