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Fig. 1 | AMB Express

Fig. 1

From: Insights into the antimicrobial effects of ceritinib against Staphylococcus aureus in vitro and in vivo by cell membrane disruption

Fig. 1

Anti-biofilm effects of CERI against S. aureus. Dose-dependent biofilm inhibition effect of CERI was determined using 0.25% crystal violet staining (A) and viable cell counting assay (B) after exposure for 24 h. Dose-dependent biofilm eradication effect of CERI was determined using 0.25% crystal violet staining (C) and viable cell counting assay (D) after forming mature biofilm and exposure for 24 h. STYO 9 and PI staining of MRSA ATCC 43300 in biofilm inhibition (E) and eradication (F) were observed by CLSM (×40) after exposure in CERI or DMSO for 30 min. Scale bars, 20 μm. Fluorescence intensity quantification analysis of the total biofilm biomass of biofilm inhibition (G) and biofilm eradication (H). The experiments were carried out in three biological repeats, and results correspond to average ± SD. The data were analyzed using one-way ANOVA with Dunnett’s multiple comparison test. Results were considered highly significant when ***P < 0.001 and ****P < 0.0001

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